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Symbol
Name
ID

Mlh1
mutL homolog 1
MGI:101938

Phenotype annotations related to digestive/alimentary system

Darker colors indicate more annotations

Human Phenotypes

Gastrointestinal hemorrhage

Neoplasm of the rectum

Colonic diverticula

Adenocarcinoma of the colon

Hereditary nonpolyposis colorectal carcinoma

Adenomatous colonic polyposis

Colon cancer

Intestinal polyposis

Neoplasm of the stomach

Constipation

Nausea and vomiting

Neoplasm of the liver

Hepatocellular carcinoma

Benign gastrointestinal tract tumors

Adenocarcinoma of the small intestine

Duodenal adenocarcinoma

Disease(s) Associated with MLH1

colorectal cancer

hereditary nonpolyposis colorectal cancer type 2

Lynch syndrome

mismatch repair cancer syndrome

Muir-Torre syndrome

Mouse Phenotypes		increased gastrointestinal tumor incidence	increased intestinal adenocarcinoma incidence	increased small intestine adenocarcinoma incidence	increased intestinal adenoma incidence
Availability	Mouse Genotype	increased gastrointestinal tumor incidence	increased intestinal adenocarcinoma incidence	increased small intestine adenocarcinoma incidence	increased intestinal adenoma incidence
	Mlh1^tm1Lisk/Mlh1^tm1Lisk
	Mlh1^tm1Rak/Mlh1^tm1Rak
	Mlh1^tm1Rak/Mlh1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23